Recent advances in the molecular understanding of immunoglobulin A
Yuxin Wang, Junyu Xiao
Abstract
Immunoglobulin A (IgA) plays a crucial role in the human immune system, particularly in mucosal immunity. IgA antibodies that target the mucosal surface are made up of two to five IgA monomers linked together by the joining chain, forming polymeric molecules. These IgA polymers are transported across mucosal epithelial cells by the polymeric immunoglobulin receptor pIgR, resulting in the formation of secretory IgA (SIgA). This review aims to explore recent advancements in our molecular understanding of IgA, with a specific focus on SIgA, and the interaction between IgA and pathogen molecules.
Topics & Concepts
Polymeric immunoglobulin receptorSecretory componentAntibodyImmunoglobulin AJ chainSecretory IgAImmune systemImmunoglobulin EImmunologyBiologyReceptorMucosal immunityImmunoglobulin GImmunityChemistryBiochemistryGlycosylation and Glycoproteins ResearchGalectins and Cancer BiologyMonoclonal and Polyclonal Antibodies Research