Uric Acid-to-Albumin Ratio: A Novel Marker for the Extent of Coronary Artery Disease in Patients with Non-ST-Elevated Myocardial Infarction
Ender Özgün Çakmak, Emrah Bayam, Mehmet Çelık, Muzaffer Kahyaoğlu, Kıvanç Eren, Elmin Imanov, Ali Karagöz, İbrahim Akın İzgi
Abstract
<b><i>Objective:</i></b> This research aimed to investigate the predictive value of the uric acid-to-serum albumin ratio (UAR) in establishing the severity and extent of coronary artery disease (CAD) with non-ST segment elevation myocardial infarction (NSTEMI) patients. <b><i>Methods:</i></b> A total of 402 patients (mean age 63.5 ± 11.6 years) were included in this retrospectively designed study. We compared Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery Scores (SS) between low (≤22) and intermediate-high (&#x3e;22) groups. The UAR, the neutrophil-to-lymphocyte ratio (NLR), and the C-reactive protein-to-albumin ratio (CAR) were evaluated and compared. <b><i>Results:</i></b> SS &#x3e;22 were observed in 30.8% (<i>n</i> = 124) of the patients, and their UAR, NLR, and CAR were significantly higher. Three separate multivariate analysis models performed as the outcome of a reliable correlation between UAR, NLR, CAR, and consequently UAR (OR = 2.08; 95% CI 1.21–3.58; <i>p</i> = 0.008) and CAR (OR = 3.33; 95% CI 1.85–5.9; <i>p</i> &#x3c; 0.001) reached significance but NLR (OR = 1.26; 95% CI 0.86–1.84; <i>p</i> = 0.20) clinically trended significance (not statistically). Model performance comparisons demonstrated that UAR is a better predictor regarding likelihood ratios (UAR, 60.95; NLR, 57.8; and CAR, 59.0). <b><i>Conclusion:</i></b> As a novel inflammatory marker, UAR independently predicted better outcomes than CAR and might be used reliably in prediction of the extent of CAD in NSTEMI patients.