Cephalotane diterpenoids: structural diversity, biological activity, biosynthetic proposal, and chemical synthesis
Jin‐Xin Zhao, Zhan‐Peng Ge, Jian‐Min Yue
Abstract
diterpenoids proposed as cephalotane were disclosed, which triggered intense studies on this diterpenoid family. To date, a cumulative total of 105 cephalotane diterpenoids with great structural diversity and biological importance have been isolated. In addition, significant advances have been made in the field of total synthesis and biosynthesis of cephalotanes in recent years. This review provides a complete overview of the chemical structures, bioactivities, biosynthetic aspects, and completed total synthesis of all the isolated cephalotane diterpenoids, which will help guide future research on this class of compounds.
Topics & Concepts
Diversity (politics)ChemistryBiosynthesisStereochemistryCombinatorial chemistryComputational biologyBiochemistryBiologySociologyEnzymeAnthropologyBiological Activity of Diterpenoids and BiflavonoidsNatural product bioactivities and synthesisBioactive Natural Diterpenoids Research