Fabrication and compatibility evaluation of polycaprolactone/hydroxyapatite/collagen-based fiber scaffold for anterior cruciate ligament injury
Aminatun, Faika Hanum S., Djoni Izak R, Sofijan Hadi, Tahta Amrillah, Che Azurahanim Che Abdullah
Abstract
. The average fiber diameter in all samples was less than 1000 nm. The model with the best characterization was PCL : HA : collagen with a weight-to-weight (wt%) ratio of 50 : 45 : 5 and an average fiber diameter of 488 ± 271 nm. The UTS and modulus of elasticity for braided samples were 2.796 MPa and 3.224 MPa, respectively, while the non-braided samples were 2.864 MPa and 12.942 MPa. The estimated time of degradation was 9.44 months. It was also revealed to be non-toxic, with an 87.95% viable cell percentage.
Topics & Concepts
PolycaprolactoneCompatibility (geochemistry)ScaffoldAnterior cruciate ligamentFabricationMaterials scienceBiomedical engineeringComposite materialSurgeryPolymerMedicinePathologyAlternative medicineKnee injuries and reconstruction techniquesBone Tissue Engineering MaterialsTotal Knee Arthroplasty Outcomes