Pre-clinical data supporting immunotherapy for HIV using CMV-HIV-specific CAR T cells with CMV vaccine
Min Guan, Laura Lim, Leo Holguin, Tianxu Han, Vibhuti Vyas, Ryan Urak, Aaron David Miller, Diana Browning, Liliana Echavarria, Shasha Li, Shirley Li, Wen-Chung Chang, Tristan Scott, Paul J. Yazaki, Kevin V. Morris, Angelo A. Cardoso, M. Suzette Blanchard, Virginia Le Verche, Stephen J. Forman, John A. Zaia, John Burnett, Xiuli Wang
Abstract
cells in the bone marrow upon ART interruption. Collectively, these data support the clinical development of CMV-HIV CAR T cells in combination with a CMV vaccine in HIV-infected individuals.
Topics & Concepts
Chimeric antigen receptorVirologyImmunologyHIV AntigensAntibodyCytomegalovirusBiologyAntigenT cellImmune systemMedicineHuman immunodeficiency virus (HIV)Viral diseaseHerpesviridaeCAR-T cell therapy researchImmune Cell Function and InteractionT-cell and B-cell Immunology