Acid-Free Copper-Catalyzed Electrophilic Nitration of Electron-Rich Arenes with Guanidine Nitrate
Wen-Pei Li, Guo Cheng, Si‐Yuan Li, Cheng-Zhou Lin, Xiao-Yu Guan, De-Xian Bing, Jing Cao, Di Zhu, Qing‐Hai Deng
Abstract
A practical copper-catalyzed nitration of electron-rich arenes with trimethylsilyl chloride and guanidine nitrate is reported. A variety of nitrated products were generated in moderate to excellent yields (32-99%) at ambient temperature under acid-free, open-flask, and operationally simple conditions.
Topics & Concepts
ChemistryNitrationGuanidineTrimethylsilyl chlorideElectrophileNitrateCatalysisCopperTrimethylsilylChlorideOrganic chemistryNitric acidInorganic chemistryCatalytic C–H Functionalization MethodsChemical Synthesis and ReactionsCatalytic Cross-Coupling Reactions