Glutathione and viscosity double-locked response fluorescent probe for imaging and surgical navigation of hepatocellular carcinoma
Wen Zhang, M. Zhang, Mengmei Li, Xin Wang, Ping Li, Bo Tang
Abstract
Early diagnosis and precise treatment of hepatocellular carcinoma (HCC) are crucial for human health. Therefore, addressing the potential markers of HCC, glutathione (GSH) and viscosity, we constructed a fluorescent probe (PG-V) activated cascadically by GSH/viscosity. PG-V possessed excellent photophysical properties and biocompatibility, and could specifically illuminate tumor tissue, achieving fluorescence imaging of HCC, and imaging-guided tumor resection.
Topics & Concepts
Hepatocellular carcinomaFluorescenceGlutathioneViscosityChemistryBiophysicsMedicineMaterials scienceCancer researchBiochemistryBiologyOpticsPhysicsEnzymeComposite materialNanoplatforms for cancer theranosticsSulfur Compounds in BiologyMolecular Sensors and Ion Detection