Electrochemical monofluoroalkylation cyclization of<i>N</i>-arylacrylamides to construct monofluorinated 2-oxindoles
Yanxia Lv, Zhong‐Wei Hou, Yi Wang, Pinhua Li, Lei Wang
Abstract
-arylacrylamides to synthesize monofluorinated 2-oxindoles has been developed, which employs common dimethyl 2-fluoromalonate as a monofluoroalkyl radical precursor and obviates the use of prefunctionalized monofluoroalkylation reagents and sacrificial oxidants. A variety of monofluorinated nitrogen-containing heterocyclic compounds were efficiently obtained with satisfactory yields from readily available materials.
Topics & Concepts
ReagentElectrochemistryChemistryCombinatorial chemistryOrganic chemistryElectrodePhysical chemistryFluorine in Organic ChemistryRadical Photochemical ReactionsSulfur-Based Synthesis Techniques