Activation of mTORC1 at late endosomes misdirects T cell fate decision in older individuals
Jun Jin, Chulwoo Kim, Qiong Xia, Timothy Gould, Wenqiang Cao, Huimin Zhang, Xuanying Li, Daniela Weiskopf, Alba Grifoni, Alessandro Sette, Cornelia M. Weyand, Jörg J. Goronzy
Abstract
memory T cell generation, and recall responses to infection. Thus, curtailing late endosomal mTORC1 activity is a promising strategy to enhance T cell immunity.
Topics & Concepts
EndosomemTORC1Cell biologyCellBiologyFunction (biology)Signal transductionIntracellularPI3K/AKT/mTOR pathwayGeneticsT-cell and B-cell ImmunologyImmune Cell Function and InteractionMast cells and histamine