Bioprospecting and biotechnological insights into sweet-tasting proteins by microbial hosts―a review
Muhammad Bilal, Liyun Ji, Shuo Xu, Yue Zhang, Hafiz M.N. Iqbal, Hairong Cheng
Abstract
represents an appealing choice. Engineering techniques can be applied for large-scale biosynthesis of proteins, which can be used in biopharmaceutical, food, diagnostic, and medicine industries. Nevertheless, extensive work needs to be undertaken to address technical challenges in microbial production of sweet-tasting proteins in bulk. This review spotlights historical aspects, physicochemical properties (taste, safety, stability, solubility, and cost), and recombinant biosynthesis of sweet proteins. Moreover, future opportunities for process improvement based on metabolic engineering strategies are also discussed.
Topics & Concepts
ThaumatinBiotechnologyBioprocess engineeringHigh-fructose corn syrupOverconsumptionBiopharmaceuticalYarrowiaSugarKluyveromyces lactisBiologyFood scienceBiochemical engineeringYeastBiochemistrySaccharomyces cerevisiaeProduction (economics)EconomicsEngineeringMacroeconomicsGeneBiochemical Analysis and Sensing TechniquesProbiotics and Fermented FoodsOlfactory and Sensory Function Studies