A novel FAK-degrading PROTAC molecule exhibited both anti-tumor activities and efficient MDR reversal effects
Ming-shi Xu, Xiaofan Gu, Cong Li, Li-xuan Pan, Zixia Zhu, Meng Fan, Yun Zhao, Jianfang Chen, Xuan Liu, Xiongwen Zhang
Topics & Concepts
Protein kinase BFocal adhesionMultiple drug resistanceCancer researchKinaseChemistrySignal transductionPI3K/AKT/mTOR pathwayPharmacologyCell biologyBiologyBiochemistryAntibioticsProtein Degradation and InhibitorsMultiple Myeloma Research and TreatmentsUbiquitin and proteasome pathways