2-Methoxydiol derivatives as new tubulin and HDAC dual-targeting inhibitors, displaying antitumor and antiangiogenic response
Moran Sun, Jinling Qin, Yingying Kang, Yixin Zhang, Meng-Yu Ba, Hua Yang, Yongtao Duan, Yongfang Yao
Topics & Concepts
ChemistryPharmacophoreCancer cellCell cycle checkpointApoptosisCytotoxicityTubulinA549 cellMicrotubule polymerizationMicrotubuleCancer researchCell cycleCell biologyCancerBiochemistryIn vitroBiologyGeneticsHistone Deacetylase Inhibitors ResearchSynthetic Organic Chemistry MethodsPeptidase Inhibition and Analysis