An Au bipyramids@CuZn MOF core–shell nanozyme enables universal SERS and a colorimetric dual-model bioassay
Mengdi Wang, Feng Shi, Jiayin Li, Jiayin Li, Lingfeng Min, Zhanjun Yang, Juan Li, Juan Li
Abstract
In this study, a new type of gold nano-bipyramids@CuZn bimetallic organic framework (AuNBPs@CuZn MOF) nanozyme with high peroxidase (POD)-like activity and surface enhanced Raman scattering (SERS) activity was constructed with a special core-shell structure, which can catalyze the oxidation of TMB (colourless and Raman-inactive) into ox-TMB (blue and Raman-active). An AuNBPs@CuZn MOF-enabling universal SERS and colorimetric dual-model bioassay was thus developed for biomolecules with excellent performance, and has promising application prospects in the biosensing fields.
Topics & Concepts
Bimetallic stripRaman scatteringRaman spectroscopyBiomoleculeNanotechnologyChemistryBioassayMaterials scienceMetalOpticsOrganic chemistryGeneticsPhysicsBiologyAdvanced Nanomaterials in CatalysisAdvanced biosensing and bioanalysis techniquesNanocluster Synthesis and Applications