Impact of Four Common Hydrogels on Amyloid-β (Aβ) Aggregation and Cytotoxicity: Implications for 3D Models of Alzheimer’s Disease
Laura W. Simpson, Gregory L. Szeto, Hacène Boukari, Theresa A. Good, Jennie B. Leach
Abstract
environment, it may be necessary to reevaluate aspects of protein aggregation disease models used for drug discovery.
Topics & Concepts
Self-healing hydrogelsCytotoxicityChemistryBiophysicsAmyloid (mycology)In vivoContext (archaeology)3D cell cultureHyaluronic acidCell cultureCell biologyIn vitroBiochemistryBiologyAnatomyGeneticsBiotechnologyPaleontologyOrganic chemistryInorganic chemistryAlzheimer's disease research and treatments3D Printing in Biomedical ResearchCellular Mechanics and Interactions