A Histone Deacetylase, Magnaporthe oryzae RPD3, Regulates Reproduction and Pathogenic Development in the Rice Blast Fungus
Song Hee Lee, Mohamed El-Agamy Farh, Jaejoon Lee, Young Taek Oh, Eunbyeol Cho, Jiyeun Park, Hokyoung Son, Junhyun Jeon
Abstract
RPD3 is an evolutionarily conserved class I histone deacetylase (HDAC) that plays a pivotal role in diverse cellular processes. In filamentous fungal pathogens, abrogation of the gene encoding RPD3 results in either lethality or severe growth impairment, making subsequent genetic analyses challenging. Magnaporthe oryzae is a causal agent of rice blast disease, which is responsible for significant annual yield losses in rice production.
Topics & Concepts
BiologyHistone deacetylaseFungusGeneGeneticsHistoneHDAC4Cell biologyHistone deacetylase 5ReproductionMagnaportheMagnaporthe griseaEpigeneticsHistone deacetylase 2Pathogenic fungusHDAC11HeterothallicAcetylationPhenotypeStrain (injury)MutationMicrobiologyRegulation of gene expressionModel organismYield (engineering)Filamentous fungusAscomycotaFungal proteinOryzaFungal and yeast genetics researchPlant-Microbe Interactions and ImmunityPlant Pathogens and Fungal Diseases