Fate mapping via CCR2-CreER mice reveals monocyte-to-microglia transition in development and neonatal stroke
Hong‐Ru Chen, Yu Sun, Ching‐Wen Chen, Yi-Min Kuo, Irena S. Kuan, Zheng-Rong Tiger Li, Jonah C. Short-Miller, Marchelle R. Smucker, Chia-Yi Kuan
Abstract
parenchymal microglia in selective brain regions at P24. Furthermore, this fate mapping strategy revealed an acute influx of monocytes after neonatal stroke, which gradually transformed into a ramified morphology and expressed microglial marker genes (Sall1, Tmem119, and P2RY12) for at least 62 days after injury. These results suggest an underappreciated level of monocyte-to-microglia transition in development and after neonatal stroke.
Topics & Concepts
MicrogliaCCR2MonocyteGenetically modified mouseFate mappingNeuroscienceTransgeneStroke (engine)Cell biologyBiologyImmunologyEmbryonic stem cellInflammationGeneChemokineBiochemistryPhysicsChemokine receptorThermodynamicsNeuroinflammation and Neurodegeneration MechanismsImmune cells in cancerImmune Response and Inflammation