A chemoenzymatic strategy for the efficient synthesis of amphenicol antibiotic chloramphenicol mediated by an engineered <scp>l</scp>-threonine transaldolase with high activity and stereoselectivity
Lian Xu, Dan Nie, Bingmei Su, Xinqi Xu, Juan Lin
Abstract
Chemo-enzymatic route for chloramphenicol.
Topics & Concepts
TransaldolaseChemistryStereoselectivityThreonineChloramphenicolAntibioticsCombinatorial chemistryStereochemistryCatalysisBiochemistryEnzymeGlycolysisSerinePentose phosphate pathwayBiomedical Research and PathophysiologyAmino Acid Enzymes and MetabolismEnzyme Catalysis and Immobilization