Genetic Determinants of Hydrogen Sulfide Biosynthesis in Fusobacterium nucleatum Are Required for Bacterial Fitness, Antibiotic Sensitivity, and Virulence
Yiwei Chen, Martha I. Camacho, Yimin Chen, Aadil H. Bhat, Chungyu Chang, Emily A. Peluso, Chenggang Wu, Asis Das, Hung Ton‐That
Abstract
Fusobacterium nucleatum is a key commensal anaerobe of the human oral cavity that plays a significant role in oral biofilm development and contributes to additional pathologies at extraoral sites, such as promoting preterm birth and colorectal cancer. Although F. nucleatum is known as a major producer of hydrogen sulfide (H 2 S), its genetic determinants and physiological functions are not well understood.
Topics & Concepts
LanthionineVirulenceMutantFusobacterium nucleatumMicrobiologyBiologyMethionineBacteriaGeneBiochemistryGeneticsAmino acidPorphyromonas gingivalisSulfur Compounds in BiologyOral microbiology and periodontitis researchOral and Maxillofacial Pathology