A structurally informed human protein–protein interactome reveals proteome-wide perturbations caused by disease mutations
Dapeng Xiong, Yunguang Qiu, Junfei Zhao, Yadi Zhou, Dongjin Lee, Shobhita Gupta, Mateo Torres, Weiqiang Lü, Siqi Liang, Jin Joo Kang, Charis Eng, Joseph Loscalzo, Feixiong Cheng, Haiyuan Yu
Topics & Concepts
InteractomeProteomeHuman proteome projectComputational biologyDiseaseBiologyProteomicsBioinformaticsGeneticsMedicineGeneInternal medicineBioinformatics and Genomic NetworksUbiquitin and proteasome pathwaysAdvanced Proteomics Techniques and Applications