Direct synthesis of C3-alkynyl pyrroloindolines from tryptamines <i>via</i> a visible-light-induced radical cascade reaction
Linlin Ren, Yonggong Wang, Yanman Huo, Xiaogang Tong, Chengfeng Xia
Abstract
A visible-light-induced radical cascade reaction for the direct alkynylation of tryptamines with alkynyl sulfones was developed, affording a series of C3-alkynyl pyrroloindolines in excellent yields. This method features readily available substrates, good functional group tolerability, and scalability. C3-alkynyl pyrroloindolines show great potential as useful building blocks in the preparation of complex and valuable pyrroloindoline alkaloids.
Topics & Concepts
TryptaminesChemistryCascade reactionCascadeCombinatorial chemistryAlkynylationReaction conditionsVisible spectrumPhotochemistryTryptamineOrganic chemistryCatalysisMaterials scienceOptoelectronicsChromatographyBiochemistrySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods