Tunable Synthesis of 4-Acyl- and 4-Formyl Pyrroles by Rhodium-Catalyzed Ring-Expansion of Azirines with Enaminones
Xiuli Li, Jianchao Liu, Jie‐Ping Wan
Abstract
-azirines with enaminones is presented. This protocol affords a convenient approach to the diversity-oriented synthesis of 4-acyl- and 4-formyl pyrroles with good functional group tolerance. The utility of this reaction has been demonstrated by scale-up preparation, late-stage modification of natural molecules, and synthesis of diverse derivatives.
Topics & Concepts
ChemistryRhodiumRing (chemistry)CatalysisMedicinal chemistryCombinatorial chemistryStereochemistryOrganic chemistrySynthesis and Catalytic ReactionsSynthesis and Characterization of PyrrolesCatalytic C–H Functionalization Methods