Repositioning of mifepristone as an integrated stress response activator to potentiate cisplatin efficacy in non-small cell lung cancer
Jirapat Namkaew, Jun Zhang, Norio Yamakawa, Yoshimasa Hamada, Kazue Tsugawa, Miho Oyadomari, Masato Miyake, Toyomasa Katagiri, Seiichi Oyadomari
Topics & Concepts
CisplatinMifepristoneLung cancerCancer researchMedicineIntegrated stress responsePharmacologyActivator (genetics)OncologyChemotherapyBiologyInternal medicineMessenger RNATranslation (biology)GenePregnancyGeneticsReceptorBiochemistryEndoplasmic Reticulum Stress and DiseaseHeat shock proteins researchCell death mechanisms and regulation