Asymmetric synthesis of γ-lactams under low-loading N-heterocyclic carbene catalysis
Yuxia Zhang, Ye Zhang, Jingcheng Guo, Jinna Han, Xiangui Zhou, Zhenqian Fu
Abstract
Low-loading N-heterocyclic carbene-catalyzed oxidative formal [3 + 2] annulation of enals with N -Ts diethyl aminomalonate has been successfully developed.
Topics & Concepts
ChemistryCarbeneAnnulationCatalysisCombinatorial chemistryStereochemistryMedicinal chemistryOrganic chemistryN-Heterocyclic Carbenes in Organic and Inorganic ChemistryCatalytic Cross-Coupling ReactionsCatalytic C–H Functionalization Methods