Synthesis of Lactams via Ir-Catalyzed C–H Amidation Involving Ir-Nitrene Intermediates
Jitian Liu, Wenjing Ye, Shuojin Wang, Junrong Zheng, Weiping Tang, Xiaoxun Li
Abstract
x-membered lactams were synthesized via either an amidation of sp3 C–H bonds or an electrophilic substitution of arenes via Ir-nitrene intermediates. With the employment of a readily available iridium catalyst in dichloromethane or hexafluoro-2-propanol, a wide range of lactams were synthesized in good to excellent yields with high selectivity.
Topics & Concepts
NitreneIridiumCatalysisChemistryDichloromethaneElectrophileSelectivityCombinatorial chemistryMedicinal chemistryPolymer chemistryStereochemistryOrganic chemistrySolventSynthesis and Catalytic ReactionsCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and Catalysis