Site‐Selective Activation and Stereospecific Functionalization of Bis(boronic Esters) Derived from 2‐Alkenes: Construction of Propionates and Other 1,2‐Difunctional Motifs
Ningxin Xu, John L. Holmgren, James P. Morken
Abstract
Non-directed regioselective activation of bis(boronic esters), followed by functionalization, is reported. A bulky activator is shown to selectively activate the less hindered boronic ester enabling it to undergo stereospecific cross-coupling to a variety of electrophiles. This steric-based regioselectivity provides a simple and efficient method to prepare highly functionalized, enantiomerically enriched products starting from simple alkenes.
Topics & Concepts
RegioselectivityChemistryStereospecificityElectrophileSteric effectsSurface modificationPropionatesBoronic acidCombinatorial chemistryOrganic chemistryCatalysisPhysical chemistryOrganoboron and organosilicon chemistryCatalytic Cross-Coupling ReactionsSynthetic Organic Chemistry Methods