Molecular recognition of human islet amyloid polypeptide assembly by selective oligomerization of thioflavin T
Lanlan Yu, Wenbo Zhang, Wendi Luo, Robert L. Dupont, Yang Xu, Yibing Wang, Bin Tu, Haiyan Xu, Xiaoguang Wang, Qiaojun Fang, Yanlian Yang, Chen Wang, Chenxuan Wang, Chenxuan Wang, Chenxuan Wang
Abstract
). Overall, our STM imaging and theoretical understanding at the single-molecule level provide valuable insights into the design of drug compounds using the selective oligomerization of molecular probes to recognize protein self-assembly.
Topics & Concepts
ThioflavinIsletAmyloid (mycology)ChemistryBiochemistryCell biologyBiologyMedicineDiabetes mellitusAlzheimer's diseaseEndocrinologyInternal medicineDiseaseInorganic chemistryAlzheimer's disease research and treatmentsEnzyme Structure and FunctionProtein Structure and Dynamics