Hemizygous deletion of Tbk1 worsens neuromuscular junction pathology in TDP-43 transgenic mice
Kirsten Sieverding, Johannes Ulmer, Clara Bruno, Takashi Satoh, William Tsao, Axel Freischmidt, Shizuo Akira, Philip C. Wong, Albert C. Ludolph, Karin M. Danzer, Christian S. Lobsiger, Dávid Brenner, Jochen H. Weishaupt
Topics & Concepts
TransgeneGenetically modified mouseBiologyTARDBPAutophagyGliosisDenervationMutant proteinNeuromuscular junctionMutationMutantMotor neuronCell biologyAmyotrophic lateral sclerosisNeurodegenerationProtein aggregationNeurosciencePathologyGeneticsGeneSpinal cordSOD1MedicineEndocrinologyDiseaseApoptosisAmyotrophic Lateral Sclerosis ResearchNeurogenetic and Muscular Disorders ResearchGenetic Neurodegenerative Diseases