Cylindromatosis drives synapse pruning and weakening by promoting macroautophagy through Akt-mTOR signaling
Alexis S. Zajicek, Hongyu Ruan, Huihui Dai, Mary Catherine Skolfield, Hannah Phillips, Wendi J. Burnette, Behnam Javidfar, Shao‐Cong Sun, Schahram Akbarian, Wei‐Dong Yao
Topics & Concepts
PI3K/AKT/mTOR pathwayAutophagyRHEBSynaptogenesisProtein kinase BNeuroscienceBiologySynapseCell biologySynaptic plasticityPostsynaptic potentialDeubiquitinating enzymeDendritic spineHippocampal formationUbiquitinmTORC1Signal transductionGeneticsReceptorApoptosisGeneUbiquitin and proteasome pathwaysNF-κB Signaling PathwaysAutophagy in Disease and Therapy