Retracted: Exosomes Derived From Mesenchymal Stem Cells Pretreated With Ischemic Rat Heart Extracts Promote Angiogenesis via the Delivery of DMBT1
Yi Xiao, Ye Zhang, Yuzhang Li, Nanyin Peng, Qin Liu, Danyang Qiu, Justin Cho, Cesar V. Borlongan, Guolong Yu
Abstract
-Exos. Together, these suggest that IL-22 upregulation in ischemic heart extracts can increase DMBT1 in MSCs. Exosomes derived from those MSCs deliver DMBT1 to HUVECs, thereby enhancing their migratory and proliferative activity.
Topics & Concepts
Mesenchymal stem cellMicrovesiclesAngiogenesisCell biologyChemistryExosomeStem cellPharmacologyMedicineCancer researchmicroRNABiologyBiochemistryGeneExtracellular vesicles in diseaseMicroRNA in disease regulationCircular RNAs in diseases