Distinct Energy-Coupling Factor Transporter Subunits Enable Flavin Acquisition and Extracytosolic Trafficking for Extracellular Electron Transfer in Listeria monocytogenes
Rafael Rivera‐Lugo, Shuo Huang, Frank Lee, Raphaël Méheust, Anthony T. Iavarone, Ashley M. Sidebottom, Eric Oldfield, Daniel A. Portnoy, S.H. Light
Abstract
Bacteria import vitamins and other essential compounds from their surroundings but also traffic related compounds from the cytosol to the cell envelope where they serve various functions. Studying the foodborne pathogen Listeria monocytogenes , we find that the modular use of subunits from a prominent class of bacterial transporters enables the import of environmental vitamin B 2 cofactors and the extracytosolic trafficking of a vitamin B 2 -derived cofactor that facilitates redox reactions in the cell envelope.
Topics & Concepts
Flavin groupBiochemistryCofactorBiologyProtein subunitTransmembrane domainFirmicutesTransport proteinCytosolTransmembrane proteinElectron transport chainCell biologyGeneEnzyme16S ribosomal RNAReceptorMicrobial Fuel Cells and BioremediationElectrochemical Analysis and ApplicationsListeria monocytogenes in Food Safety