Temporal Transcriptional Responses of a Vibrio alginolyticus Strain to <i>Podoviridae</i> Phage HH109 Revealed by RNA-Seq
Xixi Li, Ce Zhang, Xingkun Jin, Fucheng Wei, Fei Yu, Douglas R. Call, Zhe Zhao
Abstract
Vibrio alginolyticus is a common opportunistic pathogen that causes mass mortality in cultured marine animals. Phage HH109 lyses pathogenic V. alginolyticus strain E110 with high efficiency and thus serves as a useful model to understand the dynamic interplay of a phage and its host. Global transcriptomic responses of strain E110 post-HH109 infection were characterized by using RNA sequencing, elucidating step-by-step control by HH109, an antiphage-like responses, and the elevated expression of drug resistance. This study provides a detailed molecular description phage and V. alginolyticus, providing insight into better prevention and control of vibriosis in aquatic animals.