The Two-Component System CpxRA Represses Salmonella Pathogenicity Island 2 by Directly Acting on the <i>ssrAB</i> Regulatory Operon
Nancy León-Montes, Jessica Nava‐Galeana, Diana Rodríguez-Valverde, Jorge Soria‐Bustos, Roberto Rosales-Reyes, Sandra Rivera-Gutiérrez, Hidetada Hirakawa, Miguel A. Ares, Vı́ctor H. Bustamante, Miguel A. De la Cruz
Abstract
regulatory operon; as a consequence, expression of SsrAB target genes is decreased. Our findings reveal a novel mechanism involved in the intracellular lifestyle of Salmonella, which is expected to sense perturbations in the bacterial envelope that Salmonella faces inside host cells, as the synthesis of the T3SS-2 itself.
Topics & Concepts
OperonSalmonella entericaPathogenicity islandType three secretion systemSalmonellaBiologyGenePathogenicityComponent (thermodynamics)Two-component regulatory systemSecretionGeneticsMicrobiologyCell biologyBacteriaEscherichia coliVirulenceBiochemistryMutantPhysicsThermodynamicsSalmonella and Campylobacter epidemiologyEscherichia coli research studiesVibrio bacteria research studies