Litcius/Paper detail

Design, synthesis, and biological evaluation of dual-target COX-2/5-LOX inhibitors for the treatment of inflammation

Le Du, Shuaishuai Du, Jiaming Li, Hongwei Wang

2022Medicinal Chemistry Research13 citationsDOI

Topics & Concepts

CelecoxibChemistryCyclooxygenaseArachidonate 5-lipoxygenaseZileutonPharmacologyIC50Arachidonic acidIn vivoIn vitroDocking (animal)EnzymeAnti-inflammatoryBiochemistryMedicineBiotechnologyBiologyNursingInflammatory mediators and NSAID effectsSynthesis and biological activityBioactive Compounds and Antitumor Agents
Design, synthesis, and biological evaluation of dual-target COX-2/5-LOX inhibitors for the treatment of inflammation | Litcius