Application of novel nanomagnetic metal–organic frameworks as a catalyst for the synthesis of new pyridines and 1,4-dihydropyridines via a cooperative vinylogous anomeric based oxidation
Hassan Sepehrmansourie, Mahmoud Zarei, Mohammad Ali Zolfigol, Saeed Babaee, Sadegh Rostamnia
Abstract
Abstract Herein, a new magnetic metal–organic frameworks based on Fe 3 O 4 (NMMOFs) with porous and high surface area materials were synthesized. Then, NMMOFs were characterized by FT-IR, XRD, SEM, elemental mapping, energy dispersive X-ray (EDS), TG, DTG, VSM, and N 2 adsorption–desorption isotherms (BET). Fe 3 O 4 @Co(BDC)-NH 2 as a magnetic porous catalyst was applied for synthesis of novel fused pyridines and 1,4-dihydropyridines with pyrazole and pyrimidine moieties as suitable drug candidates under ultrasonic irradiation. The significant advantages of the presented methodology are mild, facile workup, high yields, short reaction times, high thermal stability, and reusability of the described NMMOFs catalyst.