Nyuzenamides A and B: Bicyclic Peptides with Antifungal and Cytotoxic Activity from a Marine-Derived <i>Streptomyces</i> sp.
Md. Rokon Ul Karim, Yasuko In, Tao Zhou, Enjuro Harunari, Naoya Oku, Yasuhiro Igarashi
Abstract
isolated from suspended matter in deep sea water collected in the Sea of Japan. Their structures were determined through nuclear magnetic resonance and mass spectrometry analyses in combination with X-ray crystallography and the chiral-phase gas chromatography-mass spectrometry method to comprise ten amino acid residues containing four unusual amino acids along with aromatic acyl units. Both compounds displayed antifungal activity against pathogenic fungi and cytotoxicity against P388 murine leukemia cells.
Topics & Concepts
ChemistryAntifungalStreptomycesBicyclic moleculeMass spectrometryStereochemistryCytotoxicityAmino acidBiochemistryBacteriaChromatographyMicrobiologyIn vitroBiologyGeneticsMicrobial Natural Products and BiosynthesisMarine Sponges and Natural ProductsGenomics and Phylogenetic Studies