Unraveling the role of oxidative stress and lipid status parameters in the onset of preeclampsia
Petar Cabunac, Nataša Karadžov Orlić, Daniela Ardalić, Gorica Banjac, Jasmina Ivanišević, Jelena Janać, Jelena Vekić, Aleksandra Zeljković, Marija Mihajlović, Nina Rajović, Nataša Milić, Željko Miković
Abstract
OBJECTIVE: The aim of the study was to assess the potential role of oxidative stress and lipid status in the onset of preeclampsia.METHODS: 138 high-risk pregnant women were prospectively followed. Assessment of oxidative stress (TAS, TOS, AOPP and SH groups) and lipid status (t-C, LDL-C, HDL-C, TGC, APO-A1, APO-B) was carried out during the pregnancy.RESULTS: 30 women developed preeclampsia. TGC, atherogenic index of plasma, TAS and SH levels were higher in women who subsequently developed preeclampsia (p<0.05).CONCLUSION: Oxidative stress and lipid status disturbance have a potential role in the onset of preeclampsia in high risk pregnancies.