Mechanistic insights into dopaminergic and serotonergic neurotransmission – concerted interactions with helices 5 and 6 drive the functional outcome
Tomasz Maciej Stępniewski, Arturo Mancini, Richard Ågren, Mariona Torrens‐Fontanals, Meriem Semache, Michel Bouvier, Kristoffer Sahlholm, Billy Breton, Jana Selent
Abstract
) over β-arrestin. Further experiments for serotonin receptors indicate that the reported molecular mechanism is shared by other monoaminergic neurotransmitter receptors. Ultimately, our study highlights how sequence variation in position 6.55 is used by nature to fine-tune β-arrestin recruitment and in turn receptor signaling and internalization of neurotransmitter receptors.
Topics & Concepts
SerotonergicDopaminergicNeuroscienceNeurotransmitterNeurotransmissionTransmembrane domainNeurotransmitter receptorHelix (gastropod)ChemistryReceptorBiologyDopamineSerotoninBiochemistryCentral nervous systemEcologySnailReceptor Mechanisms and SignalingNeuroscience and Neuropharmacology ResearchIon channel regulation and function