Factor VIII and Functional Protein C Activity in Critically Ill Patients With Coronavirus Disease 2019: A Case Series
Ali Tabatabai, Joseph Rabin, Jay Menaker, Ronson J. Madathil, Samuel M. Galvagno, Ashley Menne, Jonathan H. Chow, Alison Grazioli, Daniel Herr, Kenichi A. Tanaka, Thomas M. Scalea, Michael Mazzeffi
Abstract
Critically ill patients with coronavirus disease 2019 (COVID-19) have been observed to be hypercoagulable, but the mechanisms for this remain poorly described. Factor VIII is a procoagulant factor that increases during inflammation and is cleaved by activated protein C. To our knowledge, there is only 1 prior study of factor VIII and functional protein C activity in critically ill patients with COVID-19. Here, we present a case series of 10 critically ill patients with COVID-19 who had severe elevations in factor VIII activity and low normal functional protein C activity, which may have contributed to hypercoagulability.