Upregulation of IP3 receptor mediates APP-induced defects in synaptic downscaling and sleep homeostasis
Lingzhan Shao, Yan Zhang, Yuping Hao, Yong Ping
Abstract
R as a shared signaling molecule in synaptic downscaling and sleep homeostasis, and its dysregulation may lead to synaptic hyperexcitability and AD progression at early stage.
Topics & Concepts
NFATHomeostasisBiologySynaptic plasticitySleep deprivationHomeostatic plasticityNeuroscienceDownregulation and upregulationSynapseSynaptic fatigueCell biologyReceptorMetaplasticityTranscription factorGeneGeneticsCircadian rhythmAlzheimer's disease research and treatmentsNeuroinflammation and Neurodegeneration MechanismsNeuroscience and Neuropharmacology Research