The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
Wernér E.G. Müller, Meik Neufurth, Hadrian Schepler, Shunfeng Wang, Emad Tolba, Heinz C. Schröder, Xiaohong Wang
Abstract
The polymer polyphosphate, abundant in blood platelets, blocks the binding of the receptor-binding domain (RBD) of the SARS- spike (S)-protein to the angiotensin-converting enzyme 2 (ACE2) at low concentrations.
Topics & Concepts
PolyphosphateChemistryReceptorAngiotensin-converting enzyme 2Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)BiochemistryPlateletEnzymeCoronavirus disease 2019 (COVID-19)Spike ProteinPlasma protein bindingBiophysicsCell biologyBiologyImmunologyMedicineDiseaseInfectious disease (medical specialty)PathologyPhosphateCoagulation, Bradykinin, Polyphosphates, and AngioedemaSARS-CoV-2 and COVID-19 ResearchCOVID-19 Clinical Research Studies