Eupalinolide A induces autophagy via the ROS/ERK signaling pathway in hepatocellular carcinoma cells <i>in vitro</i> and <i>in vivo</i>
Yonghui Zhang, Feng Dong, Zhihao Cao, Tingting Wang, Lian Pan, Wujing Luo, Wenxuan Ding, Jiaxin Li, Lishan Jin, Huan Liu, Haoyang Zhang, Jinage Mu, Meiyue Han, Yong Wei, Xuesong Deng, Dan Liu, Po Hao, Gang Zeng, Yi Pang, Guiyuan Liu, Changlin Zhen
Abstract
phase and inducing autophagy in hepatocellular carcinoma cells. EA‑induced autophagy was mediated by reactive oxygen species (ROS) and ERK signaling activation. Specific inhibitors of ROS, autophagy and ERK inhibited EA‑induced cell death and migration. In conclusion, the present study revealed that EA may inhibit the proliferation and migration of hepatocellular carcinoma cells, highlighting its potential as a promising antitumor compound for treating hepatocellular carcinoma.
Topics & Concepts
Hepatocellular carcinomaCell cycleCancer researchAutophagyApoptosisFlow cytometryMAPK/ERK pathwayCell growthBiologyCellSignal transductionCell biologyImmunologyBiochemistryAutophagy in Disease and TherapyPlant-derived Lignans Synthesis and BioactivityBerberine and alkaloids research