An Overview of the Chemical Characteristics, Bioactivity and Achievements Regarding the Therapeutic Usage of Acetogenins from Annona cherimola Mill.
Alexandra G. Durán, M. Teresa Gutiérrez, Francisco J. R. Mejías, José M. G. Molinillo, Francisco A. Macı́as
Abstract
Annona cherimola Mill., or the custard apple, is one of the species belonging to the Annonaceae family, is widely used in traditional medicine, and has been reported to be a valuable source of bioactive compounds. A unique class of secondary metabolites derived from this family are Annonaceous acetogenins, lipophilic polyketides considered to be amongst the most potent antitumor compounds. This review provides an overview of the chemical diversity, isolation procedures, bioactivity, modes of application and synthetic derivatives of acetogenins from A. cherimola Mill.
Topics & Concepts
AnnonaceaeAnnonaAcetogeninAnnona muricataCustard-appleAnnona squamosaTraditional medicineBiologyChemistryBotanyMedicineHorticultureTraditional and Medicinal Uses of AnnonaceaeCocoa and Sweet Potato AgronomyPhytochemical compounds biological activities