Characterization of simplified nonapeptides with broad-spectrum antimicrobial activities as potential food preservatives, and their antibacterial mechanism
Zhanyi Yang, Yingxin Wei, Wanpeng Wu, Licong Zhang, Jiajun Wang, Anshan Shan
Abstract
) presented a membrane-disruptive and reactive oxygen species (ROS) accumulation mechanism to execute potent and rapid broad-spectrum antimicrobial activity without observed cytotoxicity. Moreover, they exhibited favorable antimicrobial stability regardless of high ionic strength, heat, and excessive acid-base conditions, retaining potent antimicrobial effects for chicken meat preservation. Collectively, their ultra-short sequence length and potent broad-spectrum antimicrobial capacity may be beneficial for the further development of green and safe peptide-based food preservatives.
Topics & Concepts
PreservativeAntimicrobialBroad spectrumChemistryMechanism (biology)Food PreservativesAntibacterial activityFood scienceBiologyCombinatorial chemistryBacteriaOrganic chemistryPhysicsGeneticsQuantum mechanicsProtein Hydrolysis and Bioactive PeptidesAntimicrobial Peptides and ActivitiesProbiotics and Fermented Foods