Triethylammonium Hydrogen Sulfate [Et<sub>3</sub>NH][HSO<sub>4</sub>]-Catalyzed Rapid and Efficient Multicomponent Synthesis of Pyrido[2,3-<i>d</i>]pyrimidine and Pyrazolo[3,4-<i>b</i>]pyridine Hybrids
Chetan K. Jadhav, Amol S. Nipate, Asha V. Chate, Charansingh H. Gill
Abstract
] under solvent-free conditions. The remarkable feature of the present approach is that the ionic liquid possesses dual solvent-catalytic engineering capability. Results of this study revealed that 1 mmol of the ionic liquid catalyst under solvent-free conditions at 60 °C is the best reaction parameter for the construction of fused pyridine and pyrimidine derivatives in excellent yields. The present methodology showed good results under gram-scale conditions, thereby indicating its applicability in industrial as well as academic settings in the near future.
Topics & Concepts
CatalysisPyrimidineHydrogen SulfateChemistrySulfateHydrogenMedicinal chemistryStereochemistryOrganic chemistryIonic liquidMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Biological Evaluation