A protecting group–free approach for synthesizing <i>C</i>-glycosides through glycosyl dithiocarbamates
Gefei Li, Masato Noguchi, Genki Arisaka, Yuuki Tanaka, Shin‐ichiro Shoda
Abstract
The first protection/deprotection-free process for radical C-glycosylation has been achieved through one-step preparable glycosyl dithiocarbamates (GDTCs). The Giese-type reaction and radical allylation of unprotected GDTCs were successfully performed to obtain the corresponding α-C-glycosides stereoselectively under mild reaction conditions.
Topics & Concepts
GlycosylGlycosylationGlycosideProtecting groupChemistryGroup (periodic table)Combinatorial chemistryStereochemistryOrganic chemistryBiochemistryAlkylSulfur-Based Synthesis TechniquesCarbohydrate Chemistry and SynthesisChemical Synthesis and Reactions