Targeting protein modification: a new direction for immunotherapy of pancreatic cancer
Xinyu Ge, Ke Zhang, Jie Zhu, Yuan Chen, Zhengwang Wang, Peng Wang, Peng Xu, Jie Yao
Abstract
Post-translational modifications (PTMs) alter protein conformation by covalently attaching functional groups to substrates, influencing their biological activity, mechanisms of action, and functional performance. PTMs and their interactions are essential to many critical signal transduction processes, including tumor transformation, cancer progression, and metastasis in pancreatic cancer. Additionally, advancements in tumor immunotherapy indicate that PTMs are essential in immune cell activation, transport, and energy metabolism. This study aimed to investigate the effects of different PTMs on immunotherapy for pancreatic cancer, providing new perspectives and suggesting directions for future research.