A mitochondria-localized iridium(<scp>iii</scp>) photosensitizer for two-photon photodynamic immunotherapy against melanoma
Lili Wang, Johannes Karges, Fangmian Wei, Lina Xie, Zhuoli Chen, Gilles Gasser, Liangnian Ji, Hui Chao
Abstract
An iridium( iii ) two-photon photosensitizer was demonstrated to effectively trigger melanoma cell death by a combination of ferroptosis and ICD, and also cause the systemic induction of an immune response.
Topics & Concepts
PhotosensitizerPhotodynamic therapyImmunotherapyCancer researchMelanomaImmunogenic cell deathProgrammed cell deathSuperoxideChemistrySinglet oxygenReactive oxygen speciesImmune systemCD8ApoptosisBiologyImmunologyPhotochemistryOxygenBiochemistryEnzymeOrganic chemistryNanoplatforms for cancer theranosticsCancer Immunotherapy and BiomarkersFerroptosis and cancer prognosis