Menadione inhibits thioredoxin reductase 1 via arylation at the Sec498 residue and enhances both NADPH oxidation and superoxide production in Sec498 to Cys498 substitution
Shibo Sun, Weiping Xu, Yue Zhang, Yijia Yang, Qiang Ma, Jianqiang Xu
Topics & Concepts
MenadioneSuperoxideChemistryBiochemistrySelenoproteinThioredoxin reductaseReductaseSuperoxide dismutaseGlutathioneEnzymeGlutathione peroxidaseRedox biology and oxidative stressVitamin C and Antioxidants ResearchFree Radicals and Antioxidants