RETRACTED: Efficacy of methanolic extracts of some medicinal plants on wound healing in diabetic rats
Ahmad Alsarayreh, Sawsan A. Oran, J. Shakhanbeh, Khaled M. Khleifat, Yaseen Al Qaisi, Ibrahim Alfarrayeh, Ayah M. Alkaramseh
Abstract
Background: One of the primary health concerns for diabetes individuals is wounds. The used drugs have several side effects, urging the need for new natural sources for therapeutics. Materials and methods: fruits. plant extracts were orally administered to the rats to determine their effect on the wound-healing process. Results: Plant extracts significantly increased the contraction of the wound in non-diabetic and diabetic rats (P < 0.05) and increased the fibroblast's proliferation and migration resulting in a faster healing process. The plant extracts have no cytotoxic effects. The proliferation assay exhibited the lowest cell mortality after treatment with plant extract. Conclusion: These findings may indicate that the methanolic leaf extract of the above plants can be used as new therapeutics for wound healing in diabetic patients.