Orientin downregulating oxidative stress-mediated endoplasmic reticulum stress and mitochondrial dysfunction through AMPK/SIRT1 pathway in rat nucleus pulposus cells in vitro and attenuated intervertebral disc degeneration in vivo
Zhao Zhang, Jingtao Wu, Cheng Teng, Jinquan Wang, Jiapei Yu, Chen Jin, Libo Wang, Long Wu, Zhen Lin, Ziping Yu, Zhongke Lin, Zhongke Lin, Zhongke Lin
Topics & Concepts
Endoplasmic reticulumAMPKCell biologyThapsigarginUnfolded protein responseOxidative stressBiologyApoptosisIntervertebral discEndocrinologyBiochemistryAnatomyPhosphorylationProtein kinase APain Mechanisms and TreatmentsPharmacological Effects of Natural CompoundsBee Products Chemical Analysis